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the bulk of the current information being generated from murine models of colitis [37]

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RNS, on the other hand, includes nitrogen-containing radicals such as nitric oxide (NO) and nitrogen dioxide (NO2)

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structureactivity relationships, lead optimization, and chronic in vivo efficacy